Day 1 - Networks, Berzelius-salen

09.00-09.30 An introduction to why networks can help to find diagnostic and therapeutic targets. Mikael Benson, Linköping University
09.30-10.10 Characterisation of T cell subset responses in peanut allergy using microarrays. Victor Turcanu, King's College, London
10.10-10.25 Coffee break
10.25-11.05 Personalizing molecular and physiological phenotypes. Andreas Beyer, Technische Universität Dresden, Germany
11.05-11.45 Breast Cancer Molecular Networks. Miguel Pujana, Institut d'Investigacio Biomedica de Bellvitge, Spain
11.45-13.00 Lunch
13.00-13.40 Application of systems approach in identification of cancer biomarkers. Liung Wang, Medical College of Wisconsin, USA
13.40-14.20 Inference of microRNA-regulated gene networks and functions by co-expression analysis. Sandro Banfi, Second University of Naples, Italy
14.20-14.35 Coffee break
14.35-15.15 Towards systematic analysis of metabolic fluxes in mammalian cells. Roland Nilsson, Karolinska Institute, Stockholm
15.15-15.55 Studying protein network dynamics in health and disease. Paola Picotti, Eidgenossische Technische Hochschule Zürich, Switzerland
15.55- Group discussions*
20.15- Dinner at Ghingis Khan (corner of Klostergatan/Ågatan)

* The group discussions will be based on specific questions. Those questions have been given by the participants by email before the workshop or during the day. During the lunch break we will pass around a list so that each participant can list her or himself in a group discussing those specific questions (5-7 people in each group). Light snacks and beverages will be available.

Day 2 - Model-based approaches, Berzelius-salen

Session: Model-based approaches to diagnosis
09.00-09.15 Welcome to day 2 "Model-based approaches". Gunnar Cedersund. Linköping, Sweden.
09.15-09.40 PKPD-modelling for medical diagnosis. Ron Keizer, Uppsala, Sweden.
09.40-10.05 Image-based modeling and risk analysis Andrea Schenk, Fraunhofer MEVIS, Institute for Medical Image Computing, Germany
10.05-10.30 Medical decision analysis with probabilistic graphical models. Fransisco Javier Diez, Madrid, Spain.
10.30-11.00 Coffee
11.00-11.20 Merging all of the above. Gunnar Cedersund, Linköping, Sweden.
11.20-11.40 The viewpoint of technical diagnosis. Mattias Krysander/Erik Frisk, Linköping, Sweden.
11.40-12.00 General discussion on all the tools.
12.00-13.30 Lunch

Session:Modelling for drug-development
13.30-13.45 Welcome to the afternoon session. Gunnar Cedersund, Linköping, Sweden.
13.45-14.15 Examples and showcases of modelling in drug-development. Balaji Agoram, Medimmune, AZ, UK
14.15-14.45 Examples and showcases of modelling in drug-development. Henning Schmidt, Novartis. Switzerland
14.45-15.05 Modelling the effect of a drug on a population: should it be introduced into clinical practice? Martin Henriksson. Linköping University/AstraZeneca
15.05-15.30 Coffee
15.30-16.30 Closing panel debate "Differences, similarities, and mergings of model-based and network approaches to systems medicine"*

*Some 3-5 speakers from both of the days, moderated by Mikael Benson and Gunnar Cedersund

Day 3 - Spin off event on liver diagnosis

09.15-09.30 Presentation of the Centre for Medical Image Analysis and Visualisation (CMIV). Olof Dahlqvist Leinhard, Linköping.
09.30-09.50 Needs and possibilites from a radiologists perspective. Bengt Noren, Linköping.
09.50-10.15 A top-level flux-model as a link between mechanistic multi-level modelling and clincial end-usage.
Mikael Forsgren and Gunnar Cedersund, Linkoping.
10.15-10.45 PKPD-models for liver contrast agent fluxes in rats. Jose Ulloa, AstraZeneca, GB.
10.45-11.15 Coffee

14.20-14.45 Kinetic Modeling of Human Hepatic Glucose Metabolism in T2DM. Mattias König, Berlin.
14.45-15.10 Kinetic models Hepatic Metabolism. Fianne Sips, Eindhoven, The Netherlands
12.00-13.30 Lunch

13.30-13.55 Modelling of hepatic cholesterol homeostasis in healthy and fatty liver. Damjana Rozman, Ljubljana
13.50-14.20 Image-based liver surgery planning. Andrea Schenk, Fraunhofer MEVIS, Institute for Medical Image Computing, Germany
14.20-15.15 Metabolism talks from the morning, see above
14.45-15.15 Coffee
15.15-16.00 Final Discussions
* Not confirmed speaker

See Practical information on how to get to the different lecture rooms